What compounds target HDAC6?

BiohacksAI has identified 34 compounds that interact with HDAC6 (histone deacetylase 6). Top compounds include: Vorinostat, trichostatic acid [Supplementary Concept] related to trichostatin, scriptaid, pictilisib, Valproic Acid. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HDAC6 (histone deacetylase 6)?

HDAC6 is histone deacetylase 6. It is a molecular target for 34 compounds documented in PubMed bioassay data. UniProt ID: Q9UBN7. NCBI Gene ID: 10013.

HDAC6

MOLECULAR TARGET

histone deacetylase 6

UniProt: Q9UBN7 NCBI Gene: 1001334 compounds

HDAC6 (histone deacetylase 6) is targeted by 34 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HDAC6

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Vorinostat	5.32	204
2	trichostatic acid [Supplementary Concept] related to trichostatin	5.02	150
3	scriptaid	2.94	18
4	pictilisib	1.61	4
5	Valproic Acid	1.61	4
6	Daunorubicin	1.39	3
7	Ursolic Acid	1.10	2
8	Butyric Acid	1.10	2
9	Celecoxib	1.10	2
10	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
11	chrysin	0.69	1
12	Pueraria	0.69	1
13	fisetin	0.69	1
14	Genistein	0.69	1
15	Kaempferols	0.69	1
16	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
18	pterostilbene	0.69	1
19	Quercetin	0.69	1
20	Axitinib	0.69	1
21	Bufexamac	0.69	1
22	butein	0.69	1
23	Camptothecin	0.69	1
24	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	0.69	1
25	Febuxostat	0.69	1
26	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	0.69	1
27	Hesperidin	0.69	1
28	pd98059	0.69	1
29	piceatannol	0.69	1
30	sp600125	0.69	1
31	stx64	0.69	1
32	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	0.69	1
33	triflupromazine hydrochloride	0.69	1
34	cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester [Supplementary Concept]	0.69	1

About HDAC6 as a Drug Target

HDAC6 (histone deacetylase 6) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 34 compounds with documented HDAC6 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HDAC6 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.