What compounds target HIPK4?

BiohacksAI has identified 34 compounds that interact with HIPK4 (homeodomain interacting protein kinase 4). Top compounds include: gefitinib, erlotinib, imatinib, alvocidib, foretinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HIPK4 (homeodomain interacting protein)?

HIPK4 is homeodomain interacting protein kinase 4. It is a molecular target for 34 compounds documented in PubMed bioassay data. UniProt ID: Q8NE63. NCBI Gene ID: 147746.

HIPK4

MOLECULAR TARGET

homeodomain interacting protein kinase 4

UniProt: Q8NE63 NCBI Gene: 14774634 compounds

HIPK4 (homeodomain interacting protein kinase 4) is targeted by 34 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HIPK4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	imatinib	5.47	236
4	alvocidib	4.52	91
5	foretinib	4.34	76
6	bosutinib	4.08	58
7	bi 2536	4.01	54
8	quizartinib	3.99	53
9	midostaurin	3.85	46
10	neratinib	3.66	38
11	nintedanib	3.61	36
12	canertinib	3.53	33
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	linifanib	3.33	27
16	tandutinib	3.22	24
17	lestaurtinib	3.04	20
18	ruboxistaurin	2.94	18
19	defosbarasertib	2.89	17
20	r 406	2.83	16
21	pha 665752	2.71	14
22	plx 4720	2.71	14
23	bms 345541	2.71	14
24	kw 2449	2.64	13
25	ast 487	2.56	12
26	raf 265	2.48	11
27	su 014813	2.20	8
28	rebastinib	2.20	8
29	enzastaurin	2.08	7
30	Sorafenib	1.79	5
31	Afatinib	0.69	1
32	Crizotinib	0.69	1
33	pictilisib	0.69	1
34	sp600125	0.69	1

About HIPK4 as a Drug Target

HIPK4 (homeodomain interacting protein kinase 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 34 compounds with documented HIPK4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HIPK4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.