What compounds target MAPT?

BiohacksAI has identified 59 compounds that interact with MAPT (microtubule associated protein tau). Top compounds include: Methylene Blue, Quercetin, Norepinephrine Precursor of epinephrine that is secreted by, Daunorubicin, Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAPT (microtubule associated protein)?

MAPT is microtubule associated protein tau. It is a molecular target for 59 compounds documented in PubMed bioassay data. UniProt ID: AAI14949. NCBI Gene ID: 4137.

MAPT

MOLECULAR TARGET

microtubule associated protein tau

UniProt: AAI14949 NCBI Gene: 413759 compounds

MAPT (microtubule associated protein tau) is targeted by 59 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAPT

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Methylene Blue	2.30	9
2	Quercetin	2.20	8
3	Norepinephrine Precursor of epinephrine that is secreted by	1.95	6
4	Daunorubicin	1.79	5
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	1.79	5
6	myricetin-3-O-galactopyranoside [Supplementary Concept]	1.61	4
7	plumbagin [Supplementary Concept]	1.61	4
8	piceatannol	1.61	4
9	Resveratrol	1.39	3
10	Carbidopa	1.39	3
11	Epinephrine	1.39	3
12	Ethidium	1.39	3
13	Arachidonic Acid	1.10	2
14	Catechin	1.10	2
15	egcg	1.10	2
16	Kaempferols	1.10	2
17	Cisplatin	1.10	2
18	Dantrolene Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in	1.10	2
19	Diamide	1.10	2
20	Dihydroxyphenylalanine	1.10	2
21	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	1.10	2
22	Vitamin K 3	1.10	2
23	Oxytetracycline	1.10	2
24	terreic acid	1.10	2
25	Wortmannin	1.10	2
26	agmatine	0.69	1
27	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
28	Dehydroepiandrosterone Sulfate	0.69	1
29	fisetin	0.69	1
30	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	0.69	1
31	Oleic Acid	0.69	1
32	Rosmarinic Acid	0.69	1
33	Vitamin	0.69	1
34	alpha-Linolenic Acid	0.69	1
35	Aurintricarboxylic Acid	0.69	1
36	Bilirubin	0.69	1
37	salvin [Supplementary Concept]	0.69	1
38	cefaclor	0.69	1
39	Chlorhexidine	0.69	1
40	Cholecalciferol Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of	0.69	1
41	daph	0.69	1
42	Chlorophyll Binding Proteins	0.69	1
43	Hexachlorophene	0.69	1
44	Idarubicin	0.69	1
45	juglone hydroxylase [Supplementary Concept] catalyzes	0.69	1
46	kenpaullone	0.69	1
47	Maprotiline	0.69	1
48	Methylcholanthrene	0.69	1
49	Niclosamide	0.69	1
50	Oxyphenbutazone	0.69	1

Showing top 50 of 59 compounds. Use the BiohacksAI search to explore all MAPT modulators.

About MAPT as a Drug Target

MAPT (microtubule associated protein tau) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 59 compounds with documented MAPT interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAPT inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.