What compounds target ROCK1?

BiohacksAI has identified 46 compounds that interact with ROCK1 (Rho associated coiled-coil containing protein kinase 1). Top compounds include: tofacitinib, alvocidib, ruxolitinib, bosutinib, midostaurin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ROCK1 (Rho associated coiled-coil)?

ROCK1 is Rho associated coiled-coil containing protein kinase 1. It is a molecular target for 46 compounds documented in PubMed bioassay data. NCBI Gene ID: 6093.

ROCK1

MOLECULAR TARGET

Rho associated coiled-coil containing protein kinase 1

NCBI Gene: 609346 compounds

ROCK1 (Rho associated coiled-coil containing protein kinase 1) is targeted by 46 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ROCK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tofacitinib	4.65	104
2	alvocidib	4.52	91
3	ruxolitinib	4.23	68
4	bosutinib	4.08	58
5	midostaurin	3.85	46
6	fasudil	3.66	38
7	baricitinib	3.56	34
8	y 27632	3.47	31
9	tae 684	3.43	30
10	fedratinib	3.40	29
11	hydroxyfasudil [Supplementary Concept]	3.18	23
12	dovitinib	3.09	21
13	upadacitinib	3.09	21
14	lestaurtinib	3.04	20
15	momelotinib	2.89	17
16	r 406	2.83	16
17	capivasertib	2.77	15
18	kw 2449	2.64	13
19	gsk 690693	2.64	13
20	ast 487	2.56	12
21	zotiraciclib	2.56	12
22	gsk 461364	2.40	10
23	ripasudil	2.40	10
24	hydroxyfasudil	2.40	10
25	belumosudil	2.30	9
26	su 014813	2.20	8
27	decernotinib	2.20	8
28	y 39983	2.20	8
29	rg 547	2.08	7
30	gsk 269962a	2.08	7
31	gsk 180736a	2.08	7
32	uprosertib	1.95	6
33	sel 120 free base	1.95	6
34	lx 7101	1.95	6
35	netarsudil	1.95	6
36	ucn 01	1.79	5
37	ilorasertib	1.79	5
38	afuresertib	1.79	5
39	sar 407899 free base	1.79	5
40	alsterpaullone	0.69	1
41	Crizotinib	0.69	1
42	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	0.69	1
43	kenpaullone	0.69	1
44	sp600125	0.69	1
45	bdb chembl3401984	0.69	1
46	bdb chembl3401987	0.69	1

About ROCK1 as a Drug Target

ROCK1 (Rho associated coiled-coil containing protein kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 46 compounds with documented ROCK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ROCK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.