What compounds target ROS1?

BiohacksAI has identified 30 compounds that interact with ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). Top compounds include: foretinib, tozasertib, ceritinib, midostaurin, brigatinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ROS1 (ROS proto-oncogene 1,)?

ROS1 is ROS proto-oncogene 1, receptor tyrosine kinase. It is a molecular target for 30 compounds documented in PubMed bioassay data. UniProt ID: P08922. NCBI Gene ID: 6098.

ROS1

MOLECULAR TARGET

ROS proto-oncogene 1, receptor tyrosine kinase

UniProt: P08922 NCBI Gene: 609830 compounds

ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase) is targeted by 30 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ROS1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	foretinib	4.34	76
2	tozasertib	4.33	75
3	ceritinib	4.19	65
4	midostaurin	3.85	46
5	brigatinib	3.81	44
6	pazopanib	3.69	39
7	nintedanib	3.61	36
8	tae 684	3.43	30
9	fedratinib	3.40	29
10	gilteritinib	3.40	29
11	mln 8054	3.33	27
12	Crizotinib	3.18	23
13	entrectinib	3.18	23
14	alectinib	3.18	23
15	selitrectinib	3.14	22
16	lestaurtinib	3.04	20
17	repotrectinib	3.00	19
18	ruboxistaurin	2.94	18
19	r 406	2.83	16
20	infigratinib	2.77	15
21	hesperadin	2.77	15
22	pha 665752	2.71	14
23	ast 487	2.56	12
24	lorlatinib	2.48	11
25	entospletinib	2.48	11
26	bms 754807	2.30	9
27	rebastinib	2.20	8
28	asp 3026	2.08	7
29	Afatinib	1.10	2
30	Axitinib	0.69	1

About ROS1 as a Drug Target

ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 30 compounds with documented ROS1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ROS1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.