TOP1
MOLECULAR TARGETDNA topoisomerase I
TOP1 (DNA topoisomerase I) is targeted by 10 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting TOP1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | Camptothecin | 4.93 | 138 |
| 2 | Topotecan | 3.26 | 25 |
| 3 | Irinotecan | 1.79 | 5 |
| 4 | Ethidium | 1.61 | 4 |
| 5 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | 1.10 | 2 |
| 6 | juglone hydroxylase [Supplementary Concept] catalyzes | 1.10 | 2 |
| 7 | fisetin | 0.69 | 1 |
| 8 | myricetin-3-O-galactopyranoside [Supplementary Concept] | 0.69 | 1 |
| 9 | Quercetin | 0.69 | 1 |
| 10 | Daunorubicin | 0.69 | 1 |
About TOP1 as a Drug Target
TOP1 (DNA topoisomerase I) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 10 compounds with documented TOP1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
TOP1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.