What compounds target TXK?

BiohacksAI has identified 27 compounds that interact with TXK (TXK tyrosine kinase). Top compounds include: gefitinib, erlotinib, sb 203580, ibrutinib, foretinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TXK (TXK tyrosine kinase)?

TXK is TXK tyrosine kinase. It is a molecular target for 27 compounds documented in PubMed bioassay data. UniProt ID: P42681. NCBI Gene ID: 7294.

TXK

MOLECULAR TARGET

TXK tyrosine kinase

UniProt: P42681 NCBI Gene: 729427 compounds

TXK (TXK tyrosine kinase) is targeted by 27 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TXK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	sb 203580	4.92	136
4	ibrutinib	4.86	128
5	foretinib	4.34	76
6	tozasertib	4.33	75
7	vandetanib	4.30	73
8	bosutinib	4.08	58
9	pazopanib	3.69	39
10	neratinib	3.66	38
11	nintedanib	3.61	36
12	canertinib	3.53	33
13	pelitinib	3.50	32
14	tae 684	3.43	30
15	fedratinib	3.40	29
16	acalabrutinib	3.22	24
17	lestaurtinib	3.04	20
18	spebrutinib	3.04	20
19	r 406	2.83	16
20	ritlecitinib	2.77	15
21	kw 2449	2.64	13
22	zanubrutinib	2.56	12
23	tirabrutinib	1.95	6
24	Afatinib	0.69	1
25	Axitinib	0.69	1
26	Crizotinib	0.69	1
27	Dasatinib	0.69	1

About TXK as a Drug Target

TXK (TXK tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 27 compounds with documented TXK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TXK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.