Cytochrome c-mediated apoptotic response
REACTOME PATHWAYThe Cytochrome c-mediated apoptotic response pathway (Reactome ID: R-HSA-111461) involves 3 genes and is affected by 24 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Cytochrome c-mediated apoptotic response
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | plumbagin [Supplementary Concept] | — | 300 |
| 2 | pd98059 | — | 7 |
| 3 | alsterpaullone | — | 12 |
| 4 | kenpaullone | — | 8 |
| 5 | isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from | — | 300 |
| 6 | Sorafenib | — | 300 |
| 7 | trametinib | — | 296 |
| 8 | withaferin | — | 300 |
| 9 | tyrphostin ag 1478 | — | 4 |
| 10 | Clotrimazole | — | 296 |
| 11 | sp600125 | — | 117 |
| 12 | fisetin | — | 78 |
| 13 | Progesterone | — | 299 |
| 14 | 2-Chloroadenosine 2-Chloroadenosine. | — | 300 |
| 15 | Benzalkonium Compounds | — | 299 |
| 16 | Calcimycin | — | 216 |
| 17 | daph | — | 2 |
| 18 | Diphenhydramine | — | 14 |
| 19 | ha1004 | — | 4 |
| 20 | Lithocholic Acid | — | 300 |
| 21 | Loratadine | — | 296 |
| 22 | trequinsin hydrochloride | — | 1 |
| 23 | Methylene Blue | — | 200 |
| 24 | felbinac | — | 31 |
About the Cytochrome c-mediated apoptotic response Pathway
The Cytochrome c-mediated apoptotic response pathway is catalogued in Reactome (ID: R-HSA-111461) and involves 3 genes. In the BiohacksAI corpus, 24 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CASP9, MAPK1, MAPK3.