What compounds affect the CaMK IV-mediated phosphorylation of CREB pathway?

49 compounds in the BiohacksAI corpus have documented interactions with genes in the CaMK IV-mediated phosphorylation of CREB pathway (Reactome ID: R-HSA-111932). These compounds target 5 genes within this pathway.

What genes are in the CaMK IV-mediated phosphorylation of CREB pathway?

The CaMK IV-mediated phosphorylation of CREB pathway involves 5 genes. Key genes include: CAMK2B, CAMK2D, CAMKK1, CAMKK2, CREB1.

CaMK IV-mediated phosphorylation of CREB

REACTOME PATHWAY

Reactome: R-HSA-1119325 genes49 compounds

The CaMK IV-mediated phosphorylation of CREB pathway (Reactome ID: R-HSA-111932) involves 5 genes and is affected by 49 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMK2D CAMKK1 CAMKK2 CREB1

Compounds Affecting CaMK IV-mediated phosphorylation of CREB

#	Compound	Targets Hit	Studies
1	sp600125	—	117
2	Quercetin	—	300
3	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
4	Axitinib	—	298
5	cycloheximide	—	300
6	Disulfiram	—	297
7	Azacitidine	—	298
8	Azacitidine	—	300
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	Levalbuterol	—	1,000
11	Adenosine Monophosphate Adenine nucleotide containing	—	300
12	Levalbuterol	—	297
13	Bortezomib	—	300
14	Clofarabine	—	298
15	Dactinomycin	—	297
16	Danazol	—	298
17	Emetine	—	298
18	Ethidium	—	300
19	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
20	Sulbactam	—	299
21	trequinsin hydrochloride	—	1
22	chrysin	—	300
23	Genistein	—	300
24	Testosterone	—	299
25	Ciclopirox	—	88
26	Cladribine	—	297
27	Clenbuterol	—	300
28	Corticosterone	—	300
29	Dasatinib	—	299
30	Daunorubicin	—	298
31	Dinoprostone	—	296
32	Epinephrine	—	299
33	Ethinyl Estradiol	—	300
34	Imatinib Mesylate	—	300
35	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
36	Nisoldipine	—	297
37	Nocodazole Nocodazole is	—	215
38	Masoprocol	—	300
39	Norepinephrine Precursor of epinephrine that is secreted by	—	298
40	o-Phthalaldehyde	—	300
41	Oxyphenbutazone	—	300
42	pivampicillin	—	275
43	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
44	Salmeterol Xinafoate	—	227
45	Tilorone	—	300
46	Urea	—	297
47	Sorafenib	—	300
48	alsterpaullone	—	12
49	Crizotinib	—	298

About the CaMK IV-mediated phosphorylation of CREB Pathway

The CaMK IV-mediated phosphorylation of CREB pathway is catalogued in Reactome (ID: R-HSA-111932) and involves 5 genes. In the BiohacksAI corpus, 49 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMK2D, CAMKK1, CAMKK2, CREB1.