Question 1

What compounds affect the Signaling by FGFR in disease pathway?

Accepted Answer

29 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by FGFR in disease pathway (Reactome ID: R-HSA-1226099). These compounds target 11 genes within this pathway.

Question 2

What genes are in the Signaling by FGFR in disease pathway?

Accepted Answer

The Signaling by FGFR in disease pathway involves 11 genes. Key genes include: BCR, FGF22, FGFR1, FGFR2, FGFR3, FGFR4, GRB2, PIK3R1, STAT1, STAT3.

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Axitinib	—	298
3	Dasatinib	—	299
4	Crizotinib	—	298
5	sp600125	—	117
6	19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept]	—	300
7	triolimus [Supplementary Concept]	—	33
8	pterostilbene	—	299
9	Imatinib Mesylate	—	300
10	pictilisib	—	25
11	Wortmannin	—	300
12	ly294002	—	11
13	alpelisib	—	227
14	Sirolimus	—	300
15	torin 1	—	10
16	Quercetin	—	300
17	Budesonide	—	1,000
18	Methylene Blue	—	200
19	egcg	—	300
20	Flurandrenolone	—	65
21	Hexachlorophene	—	300
22	streptonigrin	—	299
23	alsterpaullone	—	12
24	Niclosamide	—	299
25	Fingolimod Hydrochloride	—	56
26	Celecoxib	—	295
27	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
28	Acrylamide	—	300
29	Dactinomycin	—	297

BiohacksAI

Signaling by FGFR in disease

Genes in this Pathway

Compounds Affecting Signaling by FGFR in disease

About the Signaling by FGFR in disease Pathway