Interleukin-7 signaling
REACTOME PATHWAYThe Interleukin-7 signaling pathway (Reactome ID: R-HSA-1266695) involves 6 genes and is affected by 15 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Interleukin-7 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sirolimus | — | 300 |
| 2 | pictilisib | — | 25 |
| 3 | ly294002 | — | 11 |
| 4 | Sorafenib | — | 300 |
| 5 | Wortmannin | — | 300 |
| 6 | alpelisib | — | 227 |
| 7 | torin 1 | — | 10 |
| 8 | Quercetin | — | 300 |
| 9 | Methotrexate | — | 289 |
| 10 | Crizotinib | — | 298 |
| 11 | sp600125 | — | 117 |
| 12 | Axitinib | — | 298 |
| 13 | Niclosamide | — | 299 |
| 14 | Fingolimod Hydrochloride | — | 56 |
| 15 | Celecoxib | — | 295 |
About the Interleukin-7 signaling Pathway
The Interleukin-7 signaling pathway is catalogued in Reactome (ID: R-HSA-1266695) and involves 6 genes. In the BiohacksAI corpus, 15 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include JAK3, PIK3R1, PIK3R2, PIK3R3, STAT3.