What genes are in the BMAL1:CLOCK,NPAS2 activates circadian expression pathway?

The BMAL1:CLOCK,NPAS2 activates circadian expression pathway involves 6 genes. Key genes include: CARM1, CREBBP, NCOA1, PPARA, RXRA, SERPINE1.

BMAL1:CLOCK,NPAS2 activates circadian expression

Q: What compounds affect the BMAL1:CLOCK,NPAS2 activates circadian expression pathway?

89 compounds in the BiohacksAI corpus have documented interactions with genes in the BMAL1:CLOCK,NPAS2 activates circadian expression pathway (Reactome ID: R-HSA-1368108). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-13681086 genes89 compounds

The BMAL1:CLOCK,NPAS2 activates circadian expression pathway (Reactome ID: R-HSA-1368108) involves 6 genes and is affected by 89 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CREBBP NCOA1 PPARA RXRA SERPINE1

Compounds Affecting BMAL1:CLOCK,NPAS2 activates circadian expression

#	Compound	Targets Hit	Studies
1	Aldosterone	—	300
2	Arachidonic Acid	—	245
3	Gemfibrozil	—	297
4	Dehydroepiandrosterone Sulfate	—	300
5	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
6	Sulindac	—	297
7	Thyroxine	—	994
8	Progesterone	—	299
9	Vitamin	—	295
10	Calcitriol	—	300
11	Dactinomycin	—	297
12	Domperidone	—	299
13	Ethylene Chlorohydrin Used as	—	73
14	Phenol	—	297
15	Retinaldehyde	—	300
16	Ribitol	—	297
17	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
18	Stavudine	—	298
19	Sulfanilamide	—	300
20	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
21	Thyroxine	—	300
22	Xylitol	—	300
23	Genistein	—	300
24	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
25	Quercetin	—	300
26	Testosterone	—	299
27	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
28	Acetylcysteine	—	298
29	Adenosine	—	298
30	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
31	Chloral Hydrate	—	298
32	Chloralose	—	300
33	Cilostazol	—	297
34	Diflubenzuron	—	300
35	Dihydrotestosterone	—	300
36	dimethyl formamide	—	260
37	Dimethylformamide	—	300
38	Diuron	—	300
39	Ethidium	—	300
40	Ezetimibe	—	296
41	Flutamide	—	298
42	Lutein	—	300
43	Niclosamide	—	299
44	Niflumic Acid	—	300
45	Nitrofurazone	—	300
46	Oxaprozin	—	181
47	Piperazine	—	299
48	Rosuvastatin Calcium	—	216
49	Rotenone	—	300
50	Sulfamethazine	—	300

About the BMAL1:CLOCK,NPAS2 activates circadian expression Pathway

The BMAL1:CLOCK,NPAS2 activates circadian expression pathway is catalogued in Reactome (ID: R-HSA-1368108) and involves 6 genes. In the BiohacksAI corpus, 89 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CREBBP, NCOA1, PPARA, RXRA.