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Thyroxine

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

300+ PubMed studies analyzed · 8 RCTs · Evidence Score: 48.1

Research Domains

Thyroxine has been studied across 19 research domains including 🧬 Hormones, 🧠 Focus & Attention, 🫁 Liver & Detox, 😴 Sleep, 🫘 Kidney. The primary research focus is 🧬 Hormones with 54% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Thyroxine, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Thyroxine
40 shared targets
Triiodothyronine
21 shared targets
darapladib
11 shared targets
Ezetimibe
13 shared targets
Zearalenone
15 shared targets
Emodin
19 shared targets
Levonorgestrel
13 shared targets
Norgestrel
13 shared targets
Iodoacetamide
12 shared targets
Simvastatin
15 shared targets
Loading evidence profile...

This evidence profile for Thyroxine is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.