What compounds affect the Regulation of KIT signaling pathway?

32 compounds in the BiohacksAI corpus have documented interactions with genes in the Regulation of KIT signaling pathway (Reactome ID: R-HSA-1433559). These compounds target 8 genes within this pathway.

What genes are in the Regulation of KIT signaling pathway?

The Regulation of KIT signaling pathway involves 8 genes. Key genes include: FYN, GRB2, KIT, LCK, LYN, PTPN6, SRC, YES1.

Regulation of KIT signaling

REACTOME PATHWAY

Reactome: R-HSA-14335598 genes32 compounds

The Regulation of KIT signaling pathway (Reactome ID: R-HSA-1433559) involves 8 genes and is affected by 32 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FYN GRB2 KIT LCK LYN PTPN6 SRC YES1

Compounds Affecting Regulation of KIT signaling

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	Crizotinib	—	298
4	tyrphostin ag 1478	—	4
5	kenpaullone	—	8
6	Axitinib	—	298
7	sp600125	—	117
8	Quercetin	—	300
9	Afatinib	—	297
10	alsterpaullone	—	12
11	Acetic Acid Product of	—	300
12	Kaempferols	—	300
13	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
14	Cladribine	—	297
15	pictilisib	—	25
16	Pioglitazone	—	297
17	Vemurafenib	—	298
18	Resveratrol	—	298
19	Adenosine Monophosphate Adenine nucleotide containing	—	300
20	monorden	—	8
21	Niclosamide	—	299
22	piceatannol	—	300
23	Swainsonine	—	300
24	Rosmarinic Acid	—	300
25	Genistein	—	300
26	egcg	—	300
27	Avapritinib	—	246
28	Imatinib Mesylate	—	300
29	pd98059	—	7
30	N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept]	—	8
31	celastrol	—	300
32	Dactinomycin	—	297

About the Regulation of KIT signaling Pathway

The Regulation of KIT signaling pathway is catalogued in Reactome (ID: R-HSA-1433559) and involves 8 genes. In the BiohacksAI corpus, 32 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, GRB2, KIT, LCK, LYN.