Collagen degradation
REACTOME PATHWAYThe Collagen degradation pathway (Reactome ID: R-HSA-1442490) involves 8 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Collagen degradation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bisphenol A-Glycidyl Methacrylate | — | 197 |
| 2 | Kaempferols | — | 300 |
| 3 | Bortezomib | — | 300 |
| 4 | Resveratrol | — | 298 |
| 5 | Astemizole Antihistamine drug now withdrawn from | — | 280 |
| 6 | Leflunomide | — | 297 |
| 7 | Propafenone | — | 14 |
| 8 | Thioridazine | — | 35 |
| 9 | Progesterone | — | 299 |
| 10 | Hexachlorophene | — | 300 |
| 11 | Prednisolone | — | 1,000 |
| 12 | Ursolic Acid | — | 300 |
| 13 | Sulfaguanidine | — | 255 |
| 14 | Diminazene | — | 300 |
| 15 | silver sulfadiazine | — | 299 |
| 16 | Doxycycline | — | 999 |
| 17 | Triamcinolone | — | 300 |
About the Collagen degradation Pathway
The Collagen degradation pathway is catalogued in Reactome (ID: R-HSA-1442490) and involves 8 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADAM10, ADAM17, CTSL, ELANE, FURIN.