What compounds affect the HIV Life Cycle pathway?

41 compounds in the BiohacksAI corpus have documented interactions with genes in the HIV Life Cycle pathway (Reactome ID: R-HSA-162587). These compounds target 10 genes within this pathway.

What genes are in the HIV Life Cycle pathway?

The HIV Life Cycle pathway involves 10 genes. Key genes include: CCNT2, CDK7, CDK9, ERCC3, FEN1, FURIN, PSIP1, RAN, RNGTT, XPO1.

HIV Life Cycle

REACTOME PATHWAY

Reactome: R-HSA-16258710 genes41 compounds

The HIV Life Cycle pathway (Reactome ID: R-HSA-162587) involves 10 genes and is affected by 41 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CCNT2 CDK7 CDK9 ERCC3 FEN1 FURIN PSIP1 RAN RNGTT XPO1

Compounds Affecting HIV Life Cycle

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Ethidium	—	300
3	Levodopa	—	297
4	Methyldopa	—	297
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Methylene Blue	—	200
7	Quercetin	—	300
8	Aurintricarboxylic Acid	—	184
9	Norepinephrine Precursor of epinephrine that is secreted by	—	298
10	Dequalinium	—	136
11	Diiodotyrosine	—	300
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	Epinephrine	—	299
14	Idarubicin	—	299
15	piceatannol	—	300
16	Doxycycline	—	999
17	Carmine Coloring matter from	—	300
18	Cisplatin	—	300
19	Demeclocycline	—	297
20	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
21	Oxytetracycline	—	300
22	streptonigrin	—	299
23	Cefixime	—	300
24	Biotin	—	297
25	furylfuramide	—	82
26	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
27	Demeclocycline	—	5
28	Edaravone	—	298
29	alphitonin [Supplementary Concept] from	—	300
30	hydroxyfasudil [Supplementary Concept]	—	11
31	pictilisib	—	25
32	Sorafenib	—	300
33	plumbagin [Supplementary Concept]	—	300
34	oridonin	—	300
35	Diminazene	—	300
36	silver sulfadiazine	—	299
37	alsterpaullone	—	12
38	kenpaullone	—	8
39	Levamisole	—	299
40	Reserpine	—	297
41	Tripterygium	—	300

About the HIV Life Cycle Pathway

The HIV Life Cycle pathway is catalogued in Reactome (ID: R-HSA-162587) and involves 10 genes. In the BiohacksAI corpus, 41 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNT2, CDK7, CDK9, ERCC3, FEN1.