What compounds affect the Host Interactions of HIV factors pathway?

53 compounds in the BiohacksAI corpus have documented interactions with genes in the Host Interactions of HIV factors pathway (Reactome ID: R-HSA-162909). These compounds target 44 genes within this pathway.

What genes are in the Host Interactions of HIV factors pathway?

The Host Interactions of HIV factors pathway involves 44 genes. Key genes include: ADRM1, APOBEC3G, CDK9, FYN, HCK, HLA-A, KPNB1, LCK, NPM1, PSIP1.

Host Interactions of HIV factors

REACTOME PATHWAY

Reactome: R-HSA-16290944 genes53 compounds

The Host Interactions of HIV factors pathway (Reactome ID: R-HSA-162909) involves 44 genes and is affected by 53 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 APOBEC3G CDK9 FYN HCK HLA-A KPNB1 LCK NPM1 PSIP1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6+14 more

Compounds Affecting Host Interactions of HIV factors

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
4	Sorafenib	—	300
5	Crizotinib	—	298
6	Dasatinib	—	299
7	tyrphostin ag 1478	—	4
8	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
9	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
10	egcg	—	300
11	Genistein	—	300
12	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
13	kenpaullone	—	8
14	Acetic Acid Product of	—	300
15	Afatinib	—	297
16	Cefixime	—	300
17	Levodopa	—	297
18	Methylene Blue	—	200
19	Biotin	—	297
20	Ethidium	—	300
21	furylfuramide	—	82
22	Demeclocycline	—	5
23	Edaravone	—	298
24	Methyldopa	—	297
25	alphitonin [Supplementary Concept] from	—	300
26	Anthralin	—	299
27	sulfameter	—	52
28	DEAD-box RNA Helicases	—	169
29	Thioctic Acid	—	298
30	Resveratrol	—	298
31	Cefotetan	—	299
32	Dimethylphenylpiperazinium Iodide	—	33
33	mg624	—	3
34	streptonigrin	—	299
35	Thioctic Acid	—	300
36	Disulfiram	—	297
37	4-Hydroxybenzoate-3-Monooxygenase	—	300
38	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
39	chrysin	—	300
40	Quercetin	—	300
41	Axitinib	—	298
42	piceatannol	—	300
43	sp600125	—	117
44	Swainsonine	—	300
45	Rosmarinic Acid	—	300
46	plumbagin [Supplementary Concept]	—	300
47	oridonin	—	300
48	Pioglitazone	—	297
49	Harmaline	—	300
50	Chlorhexidine	—	299

About the Host Interactions of HIV factors Pathway

The Host Interactions of HIV factors pathway is catalogued in Reactome (ID: R-HSA-162909) and involves 44 genes. In the BiohacksAI corpus, 53 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, APOBEC3G, CDK9, FYN, HCK.