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BiohacksAI

Evidence-Based Biohacking

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APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

REACTOME PATHWAY
Reactome: R-HSA-17417835 genes38 compounds

The APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway (Reactome ID: R-HSA-174178) involves 35 genes and is affected by 38 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1AURKAAURKBPLK1PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4PSMB5PSMB6PSMB7PSMC1PSMC2PSMC3PSMC4PSMC5PSMC6PSMD1PSMD11PSMD12PSMD13PSMD14PSMD2+5 more

Compounds Affecting APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

#CompoundTargets HitStudies
1Bortezomib—300
2Reserpine—297
3Quercetin—300
4myricetin-3-O-galactopyranoside [Supplementary Concept]—300
5Sorafenib—300
6sp600125—117
7Axitinib—298
8Crizotinib—298
9kenpaullone—8
101-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]—54
11Apigenin 5,7,4'-trihydroxy-flavone,—300
12Luteolin 5,7,3',4'-tetrahydroxy-flavone,—150
13juglone hydroxylase [Supplementary Concept] catalyzes—279
14Disulfiram—297
15Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as—300
16fisetin—78
17Kaempferols—300
18Dasatinib—299
19hydroxyfasudil [Supplementary Concept]—11
20isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from—300
21scutellarein—113
22tamarixetin—26
23ly294002—11
24Wortmannin—300
25Oleic Acid—112
26Simvastatin—1,000
27cefaclor—299
28Hexachlorophene—300
29Lithocholic Acid—300
30Nisoldipine—297
31Oxyphenbutazone—300
32Oxytetracycline—300
334-Hydroxybenzoate-3-Monooxygenase—300
34chrysin—300
35egcg—300
36Genistein—300
37Pioglitazone—297
38Harmaline—300

About the APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Pathway

The APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway is catalogued in Reactome (ID: R-HSA-174178) and involves 35 genes. In the BiohacksAI corpus, 38 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, AURKA, AURKB, PLK1, PSMA1.