What genes are in the Telomere C-strand (Lagging Strand) Synthesis pathway?

The Telomere C-strand (Lagging Strand) Synthesis pathway involves 5 genes. Key genes include: BLM, DNA2, FEN1, PCNA, WRN.

Telomere C-strand (Lagging Strand) Synthesis

Q: What compounds affect the Telomere C-strand (Lagging Strand) Synthesis pathway?

36 compounds in the BiohacksAI corpus have documented interactions with genes in the Telomere C-strand (Lagging Strand) Synthesis pathway (Reactome ID: R-HSA-174417). These compounds target 5 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-1744175 genes36 compounds

The Telomere C-strand (Lagging Strand) Synthesis pathway (Reactome ID: R-HSA-174417) involves 5 genes and is affected by 36 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BLM DNA2 FEN1 PCNA WRN

Compounds Affecting Telomere C-strand (Lagging Strand) Synthesis

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Levodopa	—	297
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	Quercetin	—	300
5	Aurintricarboxylic Acid	—	184
6	Norepinephrine Precursor of epinephrine that is secreted by	—	298
7	Ethidium	—	300
8	Idarubicin	—	299
9	Methyldopa	—	297
10	Methylene Blue	—	200
11	Oxytetracycline	—	300
12	streptonigrin	—	299
13	Dequalinium	—	136
14	Diiodotyrosine	—	300
15	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
16	Epinephrine	—	299
17	piceatannol	—	300
18	Doxycycline	—	999
19	Carmine Coloring matter from	—	300
20	Cisplatin	—	300
21	Demeclocycline	—	297
22	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
23	Daunorubicin	—	298
24	Estramustine	—	300
25	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
26	DEAD-box RNA Helicases	—	169
27	Thioctic Acid	—	298
28	Rosmarinic Acid	—	300
29	Dihydroxyphenylalanine	—	300
30	Vitamin K 3	—	300
31	Thioctic Acid	—	300
32	alpha-Linolenic Acid	—	300
33	Masoprocol	—	300
34	Oleanolic Acid	—	300
35	Triiodothyronine	—	300
36	Uridine Triphosphate Uridine 5'-(tetrahydrogen triphosphate).	—	300

About the Telomere C-strand (Lagging Strand) Synthesis Pathway

The Telomere C-strand (Lagging Strand) Synthesis pathway is catalogued in Reactome (ID: R-HSA-174417) and involves 5 genes. In the BiohacksAI corpus, 36 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BLM, DNA2, FEN1, PCNA, WRN.