GAB1 signalosome
REACTOME PATHWAYThe GAB1 signalosome pathway (Reactome ID: R-HSA-180292) involves 5 genes and is affected by 22 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting GAB1 signalosome
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dasatinib | — | 299 |
| 2 | tyrphostin ag 1478 | — | 4 |
| 3 | Sorafenib | — | 300 |
| 4 | Quercetin | — | 300 |
| 5 | Afatinib | — | 297 |
| 6 | Resveratrol | — | 298 |
| 7 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 8 | alsterpaullone | — | 12 |
| 9 | Crizotinib | — | 298 |
| 10 | kenpaullone | — | 8 |
| 11 | monorden | — | 8 |
| 12 | Niclosamide | — | 299 |
| 13 | pictilisib | — | 25 |
| 14 | Wortmannin | — | 300 |
| 15 | ly294002 | — | 11 |
| 16 | alpelisib | — | 227 |
| 17 | Sirolimus | — | 300 |
| 18 | torin 1 | — | 10 |
| 19 | ag490 | — | 14 |
| 20 | tyrphostin 1 | — | 1 |
| 21 | Axitinib | — | 298 |
| 22 | Dactinomycin | — | 297 |
About the GAB1 signalosome Pathway
The GAB1 signalosome pathway is catalogued in Reactome (ID: R-HSA-180292) and involves 5 genes. In the BiohacksAI corpus, 22 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSK, EGFR, GRB2, PIK3R1, SRC.