FGFR1 mutant receptor activation
REACTOME PATHWAYThe FGFR1 mutant receptor activation pathway (Reactome ID: R-HSA-1839124) involves 7 genes and is affected by 27 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting FGFR1 mutant receptor activation
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Axitinib | — | 298 |
| 3 | 19-((1'S,4'R)-4'-hydroxy-1'-methoxy-2'-oxopentyl)geldanamycin [Supplementary Concept] | — | 300 |
| 4 | triolimus [Supplementary Concept] | — | 33 |
| 5 | pterostilbene | — | 299 |
| 6 | Crizotinib | — | 298 |
| 7 | Imatinib Mesylate | — | 300 |
| 8 | pictilisib | — | 25 |
| 9 | Wortmannin | — | 300 |
| 10 | ly294002 | — | 11 |
| 11 | alpelisib | — | 227 |
| 12 | Sirolimus | — | 300 |
| 13 | torin 1 | — | 10 |
| 14 | Quercetin | — | 300 |
| 15 | Budesonide | — | 1,000 |
| 16 | Methylene Blue | — | 200 |
| 17 | egcg | — | 300 |
| 18 | Flurandrenolone | — | 65 |
| 19 | Hexachlorophene | — | 300 |
| 20 | streptonigrin | — | 299 |
| 21 | alsterpaullone | — | 12 |
| 22 | Dasatinib | — | 299 |
| 23 | sp600125 | — | 117 |
| 24 | Niclosamide | — | 299 |
| 25 | Fingolimod Hydrochloride | — | 56 |
| 26 | Celecoxib | — | 295 |
| 27 | Dactinomycin | — | 297 |
About the FGFR1 mutant receptor activation Pathway
The FGFR1 mutant receptor activation pathway is catalogued in Reactome (ID: R-HSA-1839124) and involves 7 genes. In the BiohacksAI corpus, 27 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BCR, FGFR1, GRB2, PIK3R1, STAT1.