What compounds affect the SCF(Skp2)-mediated degradation of p27/p21 pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the SCF(Skp2)-mediated degradation of p27/p21 pathway (Reactome ID: R-HSA-187577). These compounds target 38 genes within this pathway.

What genes are in the SCF(Skp2)-mediated degradation of p27/p21 pathway?

The SCF(Skp2)-mediated degradation of p27/p21 pathway involves 38 genes. Key genes include: ADRM1, CCNA1, CCNE2, CDK2, CDK4, CUL1, PSMA1, PSMA2, PSMA3, PSMA4.

SCF(Skp2)-mediated degradation of p27/p21

REACTOME PATHWAY

Reactome: R-HSA-18757738 genes26 compounds

The SCF(Skp2)-mediated degradation of p27/p21 pathway (Reactome ID: R-HSA-187577) involves 38 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CCNA1 CCNE2 CDK2 CDK4 CUL1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13+8 more

Compounds Affecting SCF(Skp2)-mediated degradation of p27/p21

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	alsterpaullone	—	12
4	kenpaullone	—	8
5	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
6	sp600125	—	117
7	Disulfiram	—	297
8	4-Hydroxybenzoate-3-Monooxygenase	—	300
9	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
10	chrysin	—	300
11	egcg	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Quercetin	—	300
14	Genistein	—	300
15	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
16	Aurintricarboxylic Acid	—	184
17	Methylergonovine	—	14
18	Adenosine Triphosphate	—	300
19	candesartan cilexetil [Supplementary Concept]	—	300
20	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
21	ninhydrin	—	300
22	Pioglitazone	—	297
23	Harmaline	—	300
24	Dasatinib	—	299
25	Vemurafenib	—	298
26	indirubin	—	300

About the SCF(Skp2)-mediated degradation of p27/p21 Pathway

The SCF(Skp2)-mediated degradation of p27/p21 pathway is catalogued in Reactome (ID: R-HSA-187577) and involves 38 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CCNA1, CCNE2, CDK2, CDK4.