Degradation of beta-catenin by the destruction complex

Q: What compounds affect the Degradation of beta-catenin by the destruction complex pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the Degradation of beta-catenin by the destruction complex pathway (Reactome ID: R-HSA-195253). These compounds target 41 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-19525341 genes47 compounds

The Degradation of beta-catenin by the destruction complex pathway (Reactome ID: R-HSA-195253) involves 41 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CSNK1A1 CTBP1 CUL1 GSK3B HDAC1 PPP2CA PPP2R5A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11+11 more

Compounds Affecting Degradation of beta-catenin by the destruction complex

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Quercetin	—	300
6	chrysin	—	300
7	Sorafenib	—	300
8	egcg	—	300
9	Ursolic Acid	—	300
10	sp600125	—	117
11	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
12	ninhydrin	—	300
13	Okadaic Acid	—	300
14	alsterpaullone	—	12
15	kenpaullone	—	8
16	indirubin	—	300
17	Kaempferols	—	300
18	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
19	Lithium Chloride	—	300
20	fisetin	—	78
21	ly294002	—	11
22	Rutin	—	300
23	Oleanolic Acid	—	300
24	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
25	Disulfiram	—	297
26	4-Hydroxybenzoate-3-Monooxygenase	—	300
27	Genistein	—	300
28	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
29	Vorinostat	—	299
30	trichostatic acid [Supplementary Concept] related to trichostatin	—	300
31	scriptaid	—	53
32	Valproic Acid	—	296
33	pictilisib	—	25
34	Butyric Acid	—	300
35	Celecoxib	—	295
36	Daunorubicin	—	298
37	Camptothecin	—	300
38	NAD	—	300
39	NAD	—	300
40	NAD	—	300
41	Carmine Coloring matter from	—	300
42	Diiodotyrosine	—	300
43	candesartan cilexetil [Supplementary Concept]	—	300
44	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
45	Pioglitazone	—	297
46	Harmaline	—	300
47	pnu74654	—	6

About the Degradation of beta-catenin by the destruction complex Pathway

The Degradation of beta-catenin by the destruction complex pathway is catalogued in Reactome (ID: R-HSA-195253) and involves 41 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CSNK1A1, CTBP1, CUL1, GSK3B.