Regulation of gene expression in beta cells
REACTOME PATHWAYThe Regulation of gene expression in beta cells pathway (Reactome ID: R-HSA-210745) involves 7 genes and is affected by 21 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Regulation of gene expression in beta cells
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Progesterone | — | 299 |
| 2 | gedunin | — | 54 |
| 3 | hydroxyindoleacetic acid | — | 300 |
| 4 | Linoleic Acid | — | 300 |
| 5 | Nisoldipine | — | 297 |
| 6 | Oxyphenbutazone | — | 300 |
| 7 | Triiodothyronine | — | 300 |
| 8 | Wortmannin | — | 300 |
| 9 | Digitoxin | — | 300 |
| 10 | Digoxin | — | 299 |
| 11 | Flutamide | — | 298 |
| 12 | m084 | — | 2 |
| 13 | Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against | — | 299 |
| 14 | Aurintricarboxylic Acid | — | 184 |
| 15 | Quercetin | — | 300 |
| 16 | Demeclocycline | — | 297 |
| 17 | Niclosamide | — | 299 |
| 18 | Aldosterone | — | 300 |
| 19 | Glucose | — | 294 |
| 20 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 21 | Suramin | — | 300 |
About the Regulation of gene expression in beta cells Pathway
The Regulation of gene expression in beta cells pathway is catalogued in Reactome (ID: R-HSA-210745) and involves 7 genes. In the BiohacksAI corpus, 21 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, GCK, HNF4A, HNF4G, INS.