What compounds affect the PECAM1 interactions pathway?

28 compounds in the BiohacksAI corpus have documented interactions with genes in the PECAM1 interactions pathway (Reactome ID: R-HSA-210990). These compounds target 8 genes within this pathway.

What genes are in the PECAM1 interactions pathway?

The PECAM1 interactions pathway involves 8 genes. Key genes include: FYN, ITGAV, ITGB3, LCK, LYN, PTPN6, SRC, YES1.

PECAM1 interactions

REACTOME PATHWAY

Reactome: R-HSA-2109908 genes28 compounds

The PECAM1 interactions pathway (Reactome ID: R-HSA-210990) involves 8 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

FYN ITGAV ITGB3 LCK LYN PTPN6 SRC YES1

Compounds Affecting PECAM1 interactions

#	Compound	Targets Hit	Studies
1	Sorafenib	—	300
2	Dasatinib	—	299
3	Crizotinib	—	298
4	tyrphostin ag 1478	—	4
5	kenpaullone	—	8
6	Quercetin	—	300
7	Axitinib	—	298
8	Afatinib	—	297
9	alsterpaullone	—	12
10	Acetic Acid Product of	—	300
11	sp600125	—	117
12	Tirofiban Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in	—	299
13	Kaempferols	—	300
14	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
15	Cladribine	—	297
16	pictilisib	—	25
17	Pioglitazone	—	297
18	Vemurafenib	—	298
19	Resveratrol	—	298
20	Adenosine Monophosphate Adenine nucleotide containing	—	300
21	monorden	—	8
22	Niclosamide	—	299
23	piceatannol	—	300
24	Swainsonine	—	300
25	Rosmarinic Acid	—	300
26	Genistein	—	300
27	egcg	—	300
28	celastrol	—	300

About the PECAM1 interactions Pathway

The PECAM1 interactions pathway is catalogued in Reactome (ID: R-HSA-210990) and involves 8 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include FYN, ITGAV, ITGB3, LCK, LYN.