Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
REACTOME PATHWAYThe Synthesis of Hepoxilins (HX) and Trioxilins (TrX) pathway (Reactome ID: R-HSA-2142696) involves 1 genes and is affected by 28 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Quercetin | — | 300 |
| 2 | Masoprocol | — | 300 |
| 3 | fisetin | — | 78 |
| 4 | Tyrosine | — | 43 |
| 5 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 6 | Tyrosine | — | 300 |
| 7 | butein | — | 158 |
| 8 | celastrol | — | 300 |
| 9 | Chlorhexidine | — | 299 |
| 10 | Ciclopirox | — | 88 |
| 11 | Diiodotyrosine | — | 300 |
| 12 | Disulfiram | — | 297 |
| 13 | Epinephrine | — | 299 |
| 14 | Flecainide | — | 297 |
| 15 | Fomepizole | — | 298 |
| 16 | Gliclazide | — | 300 |
| 17 | Hexachlorophene | — | 300 |
| 18 | isoetharine | — | 112 |
| 19 | Kynurenic Acid | — | 300 |
| 20 | mg624 | — | 3 |
| 21 | Phenelzine | — | 297 |
| 22 | piceatannol | — | 300 |
| 23 | Piribedil | — | 300 |
| 24 | Procarbazine | — | 299 |
| 25 | Rimonabant | — | 300 |
| 26 | scriptaid | — | 53 |
| 27 | Dipyrone | — | 298 |
| 28 | ethopropazine hydrochloride | — | 2 |
About the Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Pathway
The Synthesis of Hepoxilins (HX) and Trioxilins (TrX) pathway is catalogued in Reactome (ID: R-HSA-2142696) and involves 1 genes. In the BiohacksAI corpus, 28 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX12.