NOTCH2 intracellular domain regulates transcription

Q: What compounds affect the NOTCH2 intracellular domain regulates transcription pathway?

46 compounds in the BiohacksAI corpus have documented interactions with genes in the NOTCH2 intracellular domain regulates transcription pathway (Reactome ID: R-HSA-2197563). These compounds target 2 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-21975632 genes46 compounds

The NOTCH2 intracellular domain regulates transcription pathway (Reactome ID: R-HSA-2197563) involves 2 genes and is affected by 46 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREB1 EP300

Compounds Affecting NOTCH2 intracellular domain regulates transcription

#	Compound	Targets Hit	Studies
1	cycloheximide	—	300
2	Disulfiram	—	297
3	Azacitidine	—	298
4	Azacitidine	—	300
5	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
6	Levalbuterol	—	1,000
7	Adenosine Monophosphate Adenine nucleotide containing	—	300
8	Levalbuterol	—	297
9	Bortezomib	—	300
10	Clofarabine	—	298
11	Dactinomycin	—	297
12	Danazol	—	298
13	Emetine	—	298
14	Ethidium	—	300
15	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
16	Sulbactam	—	299
17	trequinsin hydrochloride	—	1
18	chrysin	—	300
19	Genistein	—	300
20	Quercetin	—	300
21	Testosterone	—	299
22	Ciclopirox	—	88
23	Cladribine	—	297
24	Clenbuterol	—	300
25	Corticosterone	—	300
26	Dasatinib	—	299
27	Daunorubicin	—	298
28	Dinoprostone	—	296
29	Epinephrine	—	299
30	Ethinyl Estradiol	—	300
31	Imatinib Mesylate	—	300
32	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
33	Nisoldipine	—	297
34	Nocodazole Nocodazole is	—	215
35	Masoprocol	—	300
36	Norepinephrine Precursor of epinephrine that is secreted by	—	298
37	o-Phthalaldehyde	—	300
38	Oxyphenbutazone	—	300
39	pivampicillin	—	275
40	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
41	Salmeterol Xinafoate	—	227
42	Tilorone	—	300
43	Urea	—	297
44	plumbagin [Supplementary Concept]	—	300
45	egcg	—	300
46	11-hydroxypalmatine [Supplementary Concept]	—	238

About the NOTCH2 intracellular domain regulates transcription Pathway

The NOTCH2 intracellular domain regulates transcription pathway is catalogued in Reactome (ID: R-HSA-2197563) and involves 2 genes. In the BiohacksAI corpus, 46 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREB1, EP300.