What genes are in the Activation of gene expression by SREBF (SREBP) pathway?

The Activation of gene expression by SREBF (SREBP) pathway involves 11 genes. Key genes include: CARM1, CREBBP, CYP51A1, FASN, FDPS, HMGCR, NCOA1, PPARA, RXRA, SREBF1.

Activation of gene expression by SREBF (SREBP)

Q: What compounds affect the Activation of gene expression by SREBF (SREBP) pathway?

103 compounds in the BiohacksAI corpus have documented interactions with genes in the Activation of gene expression by SREBF (SREBP) pathway (Reactome ID: R-HSA-2426168). These compounds target 11 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-242616811 genes103 compounds

The Activation of gene expression by SREBF (SREBP) pathway (Reactome ID: R-HSA-2426168) involves 11 genes and is affected by 103 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CARM1 CREBBP CYP51A1 FASN FDPS HMGCR NCOA1 PPARA RXRA SREBF1 SREBF2

Compounds Affecting Activation of gene expression by SREBF (SREBP)

#	Compound	Targets Hit	Studies
1	Aldosterone	—	300
2	Arachidonic Acid	—	245
3	Gemfibrozil	—	297
4	Rosuvastatin Calcium	—	216
5	Oleic Acid	—	112
6	Atorvastatin	—	1,000
7	Dehydroepiandrosterone Sulfate	—	300
8	methyl 13-(alpha-naphthalene)aminodeisopropyldehydroabietate [Supplementary Concept]	—	161
9	Sulindac	—	297
10	Thyroxine	—	994
11	Progesterone	—	299
12	Vitamin	—	295
13	Calcitriol	—	300
14	Dactinomycin	—	297
15	Domperidone	—	299
16	Ethylene Chlorohydrin Used as	—	73
17	Phenol	—	297
18	Retinaldehyde	—	300
19	Ribitol	—	297
20	Sorbic Acid Mold and yeast inhibitor. Used as	—	300
21	Stavudine	—	298
22	Sulfanilamide	—	300
23	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
24	Thyroxine	—	300
25	Xylitol	—	300
26	Genistein	—	300
27	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
28	Quercetin	—	300
29	Testosterone	—	299
30	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
31	Acetylcysteine	—	298
32	Adenosine	—	298
33	Anthraquinones Compounds based on ANTHRACENES which contain two KETONES in	—	300
34	Chloral Hydrate	—	298
35	Chloralose	—	300
36	Cilostazol	—	297
37	Diflubenzuron	—	300
38	Dihydrotestosterone	—	300
39	dimethyl formamide	—	260
40	Dimethylformamide	—	300
41	Diuron	—	300
42	Ethidium	—	300
43	Ezetimibe	—	296
44	Flutamide	—	298
45	Lutein	—	300
46	Niclosamide	—	299
47	Niflumic Acid	—	300
48	Nitrofurazone	—	300
49	Oxaprozin	—	181
50	Piperazine	—	299

About the Activation of gene expression by SREBF (SREBP) Pathway

The Activation of gene expression by SREBF (SREBP) pathway is catalogued in Reactome (ID: R-HSA-2426168) and involves 11 genes. In the BiohacksAI corpus, 103 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CARM1, CREBBP, CYP51A1, FASN, FDPS.