HDACs deacetylate histones
REACTOME PATHWAYThe HDACs deacetylate histones pathway (Reactome ID: R-HSA-3214815) involves 8 genes and is affected by 19 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting HDACs deacetylate histones
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Vorinostat | — | 299 |
| 2 | trichostatic acid [Supplementary Concept] related to trichostatin | — | 300 |
| 3 | scriptaid | — | 53 |
| 4 | pictilisib | — | 25 |
| 5 | Valproic Acid | — | 296 |
| 6 | Butyric Acid | — | 300 |
| 7 | Ursolic Acid | — | 300 |
| 8 | Camptothecin | — | 300 |
| 9 | Celecoxib | — | 295 |
| 10 | Daunorubicin | — | 298 |
| 11 | Bortezomib | — | 300 |
| 12 | Chlorogenic Acid | — | 300 |
| 13 | Bufexamac | — | 137 |
| 14 | gamma-Aminobutyric Acid | — | 300 |
| 15 | Phenelzine | — | 297 |
| 16 | Berberine | — | 300 |
| 17 | Quercetin | — | 300 |
| 18 | Rutin | — | 300 |
| 19 | Biotin | — | 297 |
About the HDACs deacetylate histones Pathway
The HDACs deacetylate histones pathway is catalogued in Reactome (ID: R-HSA-3214815) and involves 8 genes. In the BiohacksAI corpus, 19 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include HDAC1, HDAC10, HDAC2, HDAC3, HDAC8.