What compounds affect the Hormone ligand-binding receptors pathway?

93 compounds in the BiohacksAI corpus have documented interactions with genes in the Hormone ligand-binding receptors pathway (Reactome ID: R-HSA-375281). These compounds target 2 genes within this pathway.

What genes are in the Hormone ligand-binding receptors pathway?

The Hormone ligand-binding receptors pathway involves 2 genes. Key genes include: GNRHR, TSHR.

Hormone ligand-binding receptors

REACTOME PATHWAY

Reactome: R-HSA-3752812 genes93 compounds

The Hormone ligand-binding receptors pathway (Reactome ID: R-HSA-375281) involves 2 genes and is affected by 93 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GNRHR TSHR

Compounds Affecting Hormone ligand-binding receptors

#	Compound	Targets Hit	Studies
1	Levalbuterol	—	1,000
2	Levalbuterol	—	297
3	Dinoprostone	—	296
4	Epinephrine	—	299
5	Lynestrenol	—	299
6	Norepinephrine Precursor of epinephrine that is secreted by	—	298
7	Salmeterol Xinafoate	—	227
8	Vincamine	—	300
9	Ethinyl Estradiol	—	300
10	Rotenone	—	300
11	Niclosamide	—	299
12	Calcimycin	—	216
13	Celecoxib	—	295
14	Hexachlorophene	—	300
15	Phenoxybenzamine	—	21
16	tyrphostin 9	—	2
17	Methylene Blue	—	200
18	Astemizole Antihistamine drug now withdrawn from	—	280
19	Clenbuterol	—	300
20	Cyclic AMP	—	300
21	Cyclic AMP	—	300
22	Fenofibrate	—	297
23	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
24	Mestranol	—	300
25	rafoxanide	—	172
26	vinpocetine	—	299
27	Chlormadinone Acetate	—	300
28	Clotrimazole	—	296
29	Danazol	—	298
30	Dasatinib	—	299
31	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
32	Digitoxin	—	300
33	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
34	Digoxin	—	299
35	Ethylenethiourea	—	300
36	Ethylestrenol	—	70
37	Ethynodiol Diacetate	—	300
38	Idazoxan	—	300
39	Maprotiline	—	299
40	Nicardipine	—	94
41	Nitrofurazone	—	300
42	o-Phthalaldehyde	—	300
43	Ouabain	—	300
44	Perphenazine	—	297
45	Phenylglyoxal	—	300
46	Piperonyl Butoxide	—	300
47	Proscillaridin	—	219
48	Retinaldehyde	—	300
49	streptonigrin	—	299
50	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	—	300

About the Hormone ligand-binding receptors Pathway

The Hormone ligand-binding receptors pathway is catalogued in Reactome (ID: R-HSA-375281) and involves 2 genes. In the BiohacksAI corpus, 93 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GNRHR, TSHR.