What compounds target TSHR?

BiohacksAI has identified 77 compounds that interact with TSHR (thyroid stimulating hormone receptor). Top compounds include: Levalbuterol, Levalbuterol, Ethinyl Estradiol, Rotenone, Niclosamide. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TSHR (thyroid stimulating hormone)?

TSHR is thyroid stimulating hormone receptor. It is a molecular target for 77 compounds documented in PubMed bioassay data. UniProt ID: P16473. NCBI Gene ID: 7253.

TSHR

MOLECULAR TARGET

thyroid stimulating hormone receptor

UniProt: P16473 NCBI Gene: 725377 compounds

TSHR (thyroid stimulating hormone receptor) is targeted by 77 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TSHR

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Levalbuterol	1.95	6
2	Levalbuterol	1.95	6
3	Ethinyl Estradiol	1.95	6
4	Rotenone	1.95	6
5	Niclosamide	1.79	5
6	Calcimycin	1.61	4
7	Celecoxib	1.61	4
8	Hexachlorophene	1.61	4
9	Phenoxybenzamine	1.61	4
10	tyrphostin 9	1.61	4
11	Methylene Blue	1.39	3
12	Astemizole Antihistamine drug now withdrawn from	1.39	3
13	Clenbuterol	1.39	3
14	Cyclic AMP	1.39	3
15	Cyclic AMP	1.39	3
16	Dinoprostone	1.39	3
17	Epinephrine	1.39	3
18	Fenofibrate	1.39	3
19	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	1.39	3
20	Lynestrenol	1.39	3
21	Mestranol	1.39	3
22	Norepinephrine Precursor of epinephrine that is secreted by	1.39	3
23	rafoxanide	1.39	3
24	vinpocetine	1.10	2
25	Chlormadinone Acetate	1.10	2
26	Clotrimazole	1.10	2
27	Danazol	1.10	2
28	Dasatinib	1.10	2
29	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	1.10	2
30	Digitoxin	1.10	2
31	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	1.10	2
32	Digoxin	1.10	2
33	Ethylenethiourea	1.10	2
34	Ethylestrenol	1.10	2
35	Ethynodiol Diacetate	1.10	2
36	Idazoxan	1.10	2
37	Maprotiline	1.10	2
38	Nicardipine	1.10	2
39	Nitrofurazone	1.10	2
40	o-Phthalaldehyde	1.10	2
41	Ouabain	1.10	2
42	Perphenazine	1.10	2
43	Phenylglyoxal	1.10	2
44	Piperonyl Butoxide	1.10	2
45	Proscillaridin	1.10	2
46	Retinaldehyde	1.10	2
47	streptonigrin	1.10	2
48	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	1.10	2
49	Toxaphene	1.10	2
50	Caffeine	0.69	1

Showing top 50 of 77 compounds. Use the BiohacksAI search to explore all TSHR modulators.

About TSHR as a Drug Target

TSHR (thyroid stimulating hormone receptor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 77 compounds with documented TSHR interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TSHR inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.