What genes are in the Enzymatic degradation of dopamine by COMT pathway?

The Enzymatic degradation of dopamine by COMT pathway involves 1 genes. Key genes include: MAOA.

Enzymatic degradation of dopamine by COMT

Q: What compounds affect the Enzymatic degradation of dopamine by COMT pathway?

33 compounds in the BiohacksAI corpus have documented interactions with genes in the Enzymatic degradation of dopamine by COMT pathway (Reactome ID: R-HSA-379397). These compounds target 1 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-3793971 genes33 compounds

The Enzymatic degradation of dopamine by COMT pathway (Reactome ID: R-HSA-379397) involves 1 genes and is affected by 33 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MAOA

Compounds Affecting Enzymatic degradation of dopamine by COMT

#	Compound	Targets Hit	Studies
1	Iproniazid	—	300
2	Moclobemide	—	299
3	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Quercetin	—	300
6	Phenelzine	—	297
7	Genistein	—	300
8	Idazoxan	—	300
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Harmaline	—	300
11	hispidol	—	13
12	Linezolid	—	298
13	Vitamin K 3	—	300
14	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	—	300
15	chrysin	—	300
16	Methylene Blue	—	200
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	plumbagin [Supplementary Concept]	—	300
19	Sirolimus	—	300
20	Rutin	—	300
21	Aripiprazole	—	298
22	auraptene	—	148
23	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
24	Famotidine	—	296
25	Fentanyl	—	300
26	Guanabenz	—	298
27	Guanfacine	—	294
28	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
29	Lynestrenol	—	299
30	1-(5,8-dihydro-1,4-dihydroxy-5,8-dioxo-2-naphthyl)-4-methylpent-3-en-1-yl cinnamate [Supplementary Concept]	—	54
31	pentamidine	—	299
32	Rilmenidine Oxazole derivative that acts as	—	300
33	Sorafenib	—	300

About the Enzymatic degradation of dopamine by COMT Pathway

The Enzymatic degradation of dopamine by COMT pathway is catalogued in Reactome (ID: R-HSA-379397) and involves 1 genes. In the BiohacksAI corpus, 33 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAOA.