BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
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Guanfacine

A centrally acting antihypertensive agent with specificity towards ADRENERGIC ALPHA-2 RECEPTORS.

294+ PubMed studies analyzed · 51 RCTs · Evidence Score: 50.7

Research Domains

Guanfacine has been studied across 15 research domains including 🧠 Focus & Attention, ❤️ Cardiovascular, 🧘 Stress & Anxiety, 🧠 Memory, 😴 Sleep. The primary research focus is 🧠 Focus & Attention with 40% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Guanfacine, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Oxymetazoline
15 shared targets
Clonidine
13 shared targets
Phentolamine
15 shared targets
Dexmedetomidine
10 shared targets
Rilmenidine
9 shared targets
Guanabenz
13 shared targets
Dihydroergotamine
15 shared targets
Ergotamine
12 shared targets
Nylidrin
10 shared targets
Yohimbine
13 shared targets
Loading evidence profile...

This evidence profile for Guanfacine is generated deterministically from 294 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.