G beta:gamma signalling through PI3Kgamma
REACTOME PATHWAYThe G beta:gamma signalling through PI3Kgamma pathway (Reactome ID: R-HSA-392451) involves 4 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting G beta:gamma signalling through PI3Kgamma
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | ly294002 | — | 11 |
| 2 | pictilisib | — | 25 |
| 3 | Wortmannin | — | 300 |
| 4 | Sirolimus | — | 300 |
| 5 | alpelisib | — | 227 |
| 6 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 7 | torin 1 | — | 10 |
| 8 | Quercetin | — | 300 |
| 9 | sp600125 | — | 117 |
| 10 | alsterpaullone | — | 12 |
| 11 | kenpaullone | — | 8 |
| 12 | hydroxyfasudil [Supplementary Concept] | — | 11 |
About the G beta:gamma signalling through PI3Kgamma Pathway
The G beta:gamma signalling through PI3Kgamma pathway is catalogued in Reactome (ID: R-HSA-392451) and involves 4 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKT3, PDPK1, PIK3CG, PIK3R5.