GP1b-IX-V activation signalling
REACTOME PATHWAYThe GP1b-IX-V activation signalling pathway (Reactome ID: R-HSA-430116) involves 3 genes and is affected by 19 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting GP1b-IX-V activation signalling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dasatinib | — | 299 |
| 2 | Sorafenib | — | 300 |
| 3 | Quercetin | — | 300 |
| 4 | Resveratrol | — | 298 |
| 5 | tyrphostin ag 1478 | — | 4 |
| 6 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 7 | Afatinib | — | 297 |
| 8 | alsterpaullone | — | 12 |
| 9 | Crizotinib | — | 298 |
| 10 | kenpaullone | — | 8 |
| 11 | monorden | — | 8 |
| 12 | Niclosamide | — | 299 |
| 13 | pictilisib | — | 25 |
| 14 | Wortmannin | — | 300 |
| 15 | ly294002 | — | 11 |
| 16 | alpelisib | — | 227 |
| 17 | Sirolimus | — | 300 |
| 18 | torin 1 | — | 10 |
| 19 | Vemurafenib | — | 298 |
About the GP1b-IX-V activation signalling Pathway
The GP1b-IX-V activation signalling pathway is catalogued in Reactome (ID: R-HSA-430116) and involves 3 genes. In the BiohacksAI corpus, 19 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PIK3R1, RAF1, SRC.