Depolymerization of the Nuclear Lamina
REACTOME PATHWAYThe Depolymerization of the Nuclear Lamina pathway (Reactome ID: R-HSA-4419969) involves 3 genes and is affected by 17 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Depolymerization of the Nuclear Lamina
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | kenpaullone | — | 8 |
| 2 | alsterpaullone | — | 12 |
| 3 | indirubin | — | 300 |
| 4 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 5 | chrysin | — | 300 |
| 6 | fisetin | — | 78 |
| 7 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 8 | Clofibrate | — | 299 |
| 9 | Fenofibrate | — | 297 |
| 10 | Sertraline | — | 1,000 |
| 11 | Cinnarizine | — | 299 |
| 12 | Clotrimazole | — | 296 |
| 13 | Rotenone | — | 300 |
| 14 | Quercetin | — | 300 |
| 15 | Sorafenib | — | 300 |
| 16 | sp600125 | — | 117 |
| 17 | Histamine | — | 300 |
About the Depolymerization of the Nuclear Lamina Pathway
The Depolymerization of the Nuclear Lamina pathway is catalogued in Reactome (ID: R-HSA-4419969) and involves 3 genes. In the BiohacksAI corpus, 17 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CCNB1, CDK1, LMNA.