CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

Q: What compounds affect the CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde pathway?

48 compounds in the BiohacksAI corpus have documented interactions with genes in the CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde pathway (Reactome ID: R-HSA-442729). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-4427294 genes48 compounds

The CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde pathway (Reactome ID: R-HSA-442729) involves 4 genes and is affected by 48 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CAMK2B CAMKK1 CAMKK2 CREB1

Compounds Affecting CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	sp600125	—	117
3	Axitinib	—	298
4	cycloheximide	—	300
5	Disulfiram	—	297
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Levalbuterol	—	1,000
10	Adenosine Monophosphate Adenine nucleotide containing	—	300
11	Levalbuterol	—	297
12	Bortezomib	—	300
13	Clofarabine	—	298
14	Dactinomycin	—	297
15	Danazol	—	298
16	Emetine	—	298
17	Ethidium	—	300
18	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
19	Sulbactam	—	299
20	trequinsin hydrochloride	—	1
21	chrysin	—	300
22	Genistein	—	300
23	Testosterone	—	299
24	Ciclopirox	—	88
25	Cladribine	—	297
26	Clenbuterol	—	300
27	Corticosterone	—	300
28	Dasatinib	—	299
29	Daunorubicin	—	298
30	Dinoprostone	—	296
31	Epinephrine	—	299
32	Ethinyl Estradiol	—	300
33	Imatinib Mesylate	—	300
34	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
35	Nisoldipine	—	297
36	Nocodazole Nocodazole is	—	215
37	Masoprocol	—	300
38	Norepinephrine Precursor of epinephrine that is secreted by	—	298
39	o-Phthalaldehyde	—	300
40	Oxyphenbutazone	—	300
41	pivampicillin	—	275
42	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
43	Salmeterol Xinafoate	—	227
44	Tilorone	—	300
45	Urea	—	297
46	KN 92 [Supplementary Concept] KN 93 isomer;	—	26
47	Sorafenib	—	300
48	Crizotinib	—	298

About the CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Pathway

The CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde pathway is catalogued in Reactome (ID: R-HSA-442729) and involves 4 genes. In the BiohacksAI corpus, 48 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CAMK2B, CAMKK1, CAMKK2, CREB1.