What compounds affect the Asparagine N-linked glycosylation pathway?

45 compounds in the BiohacksAI corpus have documented interactions with genes in the Asparagine N-linked glycosylation pathway (Reactome ID: R-HSA-446203). These compounds target 32 genes within this pathway.

What genes are in the Asparagine N-linked glycosylation pathway?

The Asparagine N-linked glycosylation pathway involves 32 genes. Key genes include: CSNK1D, CTSA, F5, FOLR1, GANAB, GRIA1, INS, MAN2A1, MPI, NEU2.

Asparagine N-linked glycosylation

REACTOME PATHWAY

Reactome: R-HSA-44620332 genes45 compounds

The Asparagine N-linked glycosylation pathway (Reactome ID: R-HSA-446203) involves 32 genes and is affected by 45 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CSNK1D CTSA F5 FOLR1 GANAB GRIA1 INS MAN2A1 MPI NEU2 NEU3 PDIA3 PSMC1 SLC17A5 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3E TUBA4A TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8+2 more

Compounds Affecting Asparagine N-linked glycosylation

#	Compound	Targets Hit	Studies
1	Colchicine	—	300
2	Nocodazole Nocodazole is	—	215
3	Vincristine	—	299
4	Noscapine	—	300
5	Podophyllotoxin	—	14
6	Demecolcine	—	246
7	Maytansine	—	300
8	vinblastine sulfate	—	81
9	Vorinostat	—	299
10	egcg	—	300
11	Oxytetracycline	—	300
12	Methotrexate	—	289
13	Zanamivir	—	297
14	Bortezomib	—	300
15	caffeic acid	—	300
16	Rutin	—	300
17	Metergoline	—	144
18	Methyldopa	—	297
19	streptonigrin	—	299
20	Tolazamide	—	169
21	Hexachlorophene	—	300
22	Clotrimazole	—	296
23	Demeclocycline	—	5
24	Edaravone	—	298
25	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	—	300
26	Glutamic Acid	—	297
27	Glutamic Acid	—	300
28	Piracetam	—	300
29	aniracetam	—	110
30	Digitoxin	—	300
31	Digoxin	—	299
32	Flutamide	—	298
33	m084	—	2
34	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	—	299
35	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
36	sp600125	—	117
37	alsterpaullone	—	12
38	pictilisib	—	25
39	Pemetrexed	—	299
40	Folic Acid	—	296
41	Oseltamivir	—	297
42	apixaban [Supplementary Concept]	—	997
43	1-Deoxynojirimycin	—	299
44	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
45	Swainsonine	—	300

About the Asparagine N-linked glycosylation Pathway

The Asparagine N-linked glycosylation pathway is catalogued in Reactome (ID: R-HSA-446203) and involves 32 genes. In the BiohacksAI corpus, 45 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CSNK1D, CTSA, F5, FOLR1, GANAB.