What genes are in the SUMOylation of immune response proteins pathway?

The SUMOylation of immune response proteins pathway involves 6 genes. Key genes include: EIF2AK2, IKBKE, NFKB2, NFKBIA, RELA, SUMO1.

SUMOylation of immune response proteins

Q: What compounds affect the SUMOylation of immune response proteins pathway?

29 compounds in the BiohacksAI corpus have documented interactions with genes in the SUMOylation of immune response proteins pathway (Reactome ID: R-HSA-4755510). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-47555106 genes29 compounds

The SUMOylation of immune response proteins pathway (Reactome ID: R-HSA-4755510) involves 6 genes and is affected by 29 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

EIF2AK2 IKBKE NFKB2 NFKBIA RELA SUMO1

Compounds Affecting SUMOylation of immune response proteins

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Resveratrol	—	298
3	Bortezomib	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Kaempferols	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	Rutin	—	300
8	Withania	—	500
9	chicoric acid	—	117
10	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
11	tamarixetin	—	26
12	withaferin	—	300
13	Crizotinib	—	298
14	Podophyllotoxin	—	14
15	Voriconazole	—	299
16	Cathelicidins Antimicrobial cationic peptides with	—	300
17	plumbagin [Supplementary Concept]	—	300
18	Ursolic Acid	—	300
19	Oleanolic Acid	—	300
20	pyrrolidine dithiocarbamate	—	275
21	Trifluridine	—	295
22	vinblastine sulfate	—	81
23	Cefdinir	—	298
24	Cefixime	—	300
25	Hexachlorophene	—	300
26	Oxytetracycline	—	300
27	Axitinib	—	298
28	sp600125	—	117
29	amlexanox	—	96

About the SUMOylation of immune response proteins Pathway

The SUMOylation of immune response proteins pathway is catalogued in Reactome (ID: R-HSA-4755510) and involves 6 genes. In the BiohacksAI corpus, 29 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include EIF2AK2, IKBKE, NFKB2, NFKBIA, RELA.