What compounds target RELA?

BiohacksAI has identified 151 compounds that interact with RELA (RELA proto-oncogene, NF-kB subunit). Top compounds include: gefitinib, betulin, mangostin, rocaglamide, gartanin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is RELA (RELA proto-oncogene, NF-kB)?

RELA is RELA proto-oncogene, NF-kB subunit. It is a molecular target for 151 compounds documented in PubMed bioassay data. UniProt ID: Q04206. NCBI Gene ID: 5970.

RELA

MOLECULAR TARGET

RELA proto-oncogene, NF-kB subunit

UniProt: Q04206 NCBI Gene: 5970151 compounds

RELA (RELA proto-oncogene, NF-kB subunit) is targeted by 151 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting RELA

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	betulin	4.25	69
3	mangostin	4.14	62
4	rocaglamide	2.89	17
5	gartanin	2.71	14
6	as 602868	2.56	12
7	alphitolic acid	2.48	11
8	8 deoxygartanin	2.20	8
9	Quercetin	2.08	7
10	garcinone d	1.95	6
11	Resveratrol	1.39	3
12	Bortezomib	1.10	2
13	Podophyllotoxin	1.10	2
14	Voriconazole	1.10	2
15	agastache rugosa	1.00	1
16	Garlic	1.00	1
17	allium tuberosum	1.00	1
18	aloe vera	1.00	1
19	anemarrhena asphodeloides	1.00	1
20	apis mellifera	1.00	1
21	arctium lappa	1.00	1
22	Areca	1.00	1
23	artemisia annua	1.00	1
24	artemisia capillaris	1.00	1
25	aster tataricus	1.00	1
26	atractylodes macrocephala	1.00	1
27	bupleurum chinense	1.00	1
28	carthamus tinctorius	1.00	1
29	Centella	1.00	1
30	chaenomeles speciosa	1.00	1
31	cimicifuga heracleifolia	1.00	1
32	citrus reticulata	1.00	1
33	crataegus pinnatifida	1.00	1
34	Curcuma	1.00	1
35	cuscuta chinensis	1.00	1
36	cynomorium songaricum	1.00	1
37	dimocarpus longan	1.00	1
38	ephedra sinica	1.00	1
39	epimedium brevicornum	1.00	1
40	eriobotrya japonica	1.00	1
41	eucommia ulmoides	1.00	1
42	forsythia suspensa	1.00	1
43	fritillaria cirrhosa	1.00	1
44	gastrodia elata	1.00	1
45	Ginkgo biloba	1.00	1
46	glycine max	1.00	1
47	glycyrrhiza uralensis	1.00	1
48	lilium lancifolium	1.00	1
49	litchi chinensis	1.00	1
50	lithospermum erythrorhizon	1.00	1

Showing top 50 of 151 compounds. Use the BiohacksAI search to explore all RELA modulators.

About RELA as a Drug Target

RELA (RELA proto-oncogene, NF-kB subunit) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 151 compounds with documented RELA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

RELA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.