RA biosynthesis pathway
REACTOME PATHWAYThe RA biosynthesis pathway pathway (Reactome ID: R-HSA-5365859) involves 2 genes and is affected by 8 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting RA biosynthesis pathway
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Indomethacin | — | 297 |
| 2 | Naproxen | — | 1,000 |
| 3 | Medroxyprogesterone Acetate | — | 299 |
| 4 | Berberine | — | 300 |
| 5 | Linoleic Acid | — | 300 |
| 6 | Bimatoprost | — | 297 |
| 7 | Disulfiram | — | 297 |
| 8 | Perphenazine | — | 297 |
About the RA biosynthesis pathway Pathway
The RA biosynthesis pathway pathway is catalogued in Reactome (ID: R-HSA-5365859) and involves 2 genes. In the BiohacksAI corpus, 8 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include AKR1C3, ALDH1A1.