Question 1

What compounds affect the Phase 4 - resting membrane potential pathway?

Accepted Answer

22 compounds in the BiohacksAI corpus have documented interactions with genes in the Phase 4 - resting membrane potential pathway (Reactome ID: R-HSA-5576886). These compounds target 8 genes within this pathway.

Question 2

What genes are in the Phase 4 - resting membrane potential pathway?

Accepted Answer

The Phase 4 - resting membrane potential pathway involves 8 genes. Key genes include: KCNJ4, KCNK10, KCNK16, KCNK18, KCNK2, KCNK3, KCNK4, KCNK5.

#	Compound	Targets Hit	Studies
1	Arachidonic Acid	—	245
2	Quinidine	—	298
3	Carvedilol	—	296
4	Riluzole	—	298
5	auraptene	—	148
6	Clotrimazole	—	296
7	17 alpha-Hydroxyprogesterone Caproate Hydroxyprogesterone derivative that acts as	—	287
8	Bisphenol A-Glycidyl Methacrylate	—	197
9	Fluoxymesterone	—	278
10	Miconazole	—	298
11	Oxyphenbutazone	—	300
12	Testosterone Propionate	—	300
13	Amlodipine	—	1,000
14	Flunarizine Flunarizine is	—	299
15	Fluspirilene	—	74
16	Dehydroepiandrosterone Sulfate	—	300
17	Linoleic Acid	—	300
18	Lysophosphatidylcholines Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes	—	300
19	Spermidine	—	241
20	Putrescine	—	300
21	SCH 23390 [Supplementary Concept]	—	126
22	Spermine	—	300

BiohacksAI

Phase 4 - resting membrane potential

Genes in this Pathway

Compounds Affecting Phase 4 - resting membrane potential

About the Phase 4 - resting membrane potential Pathway