Degradation of GLI1 by the proteasome
REACTOME PATHWAYThe Degradation of GLI1 by the proteasome pathway (Reactome ID: R-HSA-5610780) involves 37 genes and is affected by 20 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Degradation of GLI1 by the proteasome
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bortezomib | — | 300 |
| 2 | Reserpine | — | 297 |
| 3 | hydroxyfasudil [Supplementary Concept] | — | 11 |
| 4 | Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as | — | 300 |
| 5 | ninhydrin | — | 300 |
| 6 | Disulfiram | — | 297 |
| 7 | 4-Hydroxybenzoate-3-Monooxygenase | — | 300 |
| 8 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 9 | chrysin | — | 300 |
| 10 | egcg | — | 300 |
| 11 | Luteolin 5,7,3',4'-tetrahydroxy-flavone, | — | 150 |
| 12 | Quercetin | — | 300 |
| 13 | Genistein | — | 300 |
| 14 | myricetin-3-O-galactopyranoside [Supplementary Concept] | — | 300 |
| 15 | candesartan cilexetil [Supplementary Concept] | — | 300 |
| 16 | Cetylpyridinium Cationic bactericidal surfactant used as | — | 300 |
| 17 | alpelisib | — | 227 |
| 18 | Pioglitazone | — | 297 |
| 19 | Harmaline | — | 300 |
| 20 | Sphingosine | — | 300 |
About the Degradation of GLI1 by the proteasome Pathway
The Degradation of GLI1 by the proteasome pathway is catalogued in Reactome (ID: R-HSA-5610780) and involves 37 genes. In the BiohacksAI corpus, 20 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CUL1, PRKACA, PRKACB, PRKACG.