What compounds affect the Degradation of GLI2 by the proteasome pathway?

34 compounds in the BiohacksAI corpus have documented interactions with genes in the Degradation of GLI2 by the proteasome pathway (Reactome ID: R-HSA-5610783). These compounds target 39 genes within this pathway.

What genes are in the Degradation of GLI2 by the proteasome pathway?

The Degradation of GLI2 by the proteasome pathway involves 39 genes. Key genes include: ADRM1, CSNK1A1, CUL1, GSK3B, PRKACA, PRKACB, PRKACG, PSMA1, PSMA2, PSMA3.

Degradation of GLI2 by the proteasome

REACTOME PATHWAY

Reactome: R-HSA-561078339 genes34 compounds

The Degradation of GLI2 by the proteasome pathway (Reactome ID: R-HSA-5610783) involves 39 genes and is affected by 34 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CSNK1A1 CUL1 GSK3B PRKACA PRKACB PRKACG PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12+9 more

Compounds Affecting Degradation of GLI2 by the proteasome

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	hydroxyfasudil [Supplementary Concept]	—	11
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Quercetin	—	300
7	chrysin	—	300
8	Sorafenib	—	300
9	egcg	—	300
10	sp600125	—	117
11	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
12	ninhydrin	—	300
13	alsterpaullone	—	12
14	kenpaullone	—	8
15	indirubin	—	300
16	Kaempferols	—	300
17	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
18	Lithium Chloride	—	300
19	fisetin	—	78
20	ly294002	—	11
21	Rutin	—	300
22	Ursolic Acid	—	300
23	Oleanolic Acid	—	300
24	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
25	Disulfiram	—	297
26	4-Hydroxybenzoate-3-Monooxygenase	—	300
27	Genistein	—	300
28	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
29	candesartan cilexetil [Supplementary Concept]	—	300
30	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
31	alpelisib	—	227
32	Pioglitazone	—	297
33	Harmaline	—	300
34	Sphingosine	—	300

About the Degradation of GLI2 by the proteasome Pathway

The Degradation of GLI2 by the proteasome pathway is catalogued in Reactome (ID: R-HSA-5610783) and involves 39 genes. In the BiohacksAI corpus, 34 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CSNK1A1, CUL1, GSK3B, PRKACA.