What compounds affect the RHO GTPases regulate CFTR trafficking pathway?

66 compounds in the BiohacksAI corpus have documented interactions with genes in the RHO GTPases regulate CFTR trafficking pathway (Reactome ID: R-HSA-5627083). These compounds target 1 genes within this pathway.

What genes are in the RHO GTPases regulate CFTR trafficking pathway?

The RHO GTPases regulate CFTR trafficking pathway involves 1 genes. Key genes include: CFTR.

RHO GTPases regulate CFTR trafficking

REACTOME PATHWAY

Reactome: R-HSA-56270831 genes66 compounds

The RHO GTPases regulate CFTR trafficking pathway (Reactome ID: R-HSA-5627083) involves 1 genes and is affected by 66 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CFTR

Compounds Affecting RHO GTPases regulate CFTR trafficking

#	Compound	Targets Hit	Studies
1	Genistein	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	Anisomycin	—	247
4	cycloheximide	—	300
5	kenpaullone	—	8
6	Vorinostat	—	299
7	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
8	Hydrocortisone	—	299
9	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
10	Betamethasone	—	299
11	Bumetanide	—	299
12	Chlorthalidone	—	299
13	Ethidium	—	300
14	Hydrocortisone	—	298
15	Cervugid [Supplementary Concept]	—	300
16	Medroxyprogesterone Acetate	—	299
17	Vitamin K 3	—	300
18	Mestranol	—	300
19	Nisoldipine	—	297
20	Quinestrol	—	194
21	Budesonide	—	1,000
22	Methylene Blue	—	200
23	Prednisolone	—	1,000
24	6-Aminonicotinamide	—	300
25	alsterpaullone	—	12
26	Hyoscyamine	—	296
27	Beclomethasone	—	300
28	Carbazilquinone	—	48
29	Carbidopa	—	298
30	cardamonin	—	180
31	Desoximetasone	—	86
32	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
33	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
34	Digoxin	—	299
35	Dinitrochlorobenzene	—	300
36	Disulfiram	—	297
37	Flumethasone	—	179
38	Fluocinolone Acetonide	—	295
39	Fluorometholone	—	299
40	Flurandrenolone	—	65
41	gamma-Linolenic Acid	—	300
42	Glyburide	—	298
43	Halcinonide	—	88
44	Hexachlorophene	—	300
45	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
46	Medroxyprogesterone	—	298
47	Melengestrol Acetate	—	300
48	Methylprednisolone	—	299
49	Methylprednisolone Acetate Methylprednisolone derivative that is used as	—	300
50	mg624	—	3

About the RHO GTPases regulate CFTR trafficking Pathway

The RHO GTPases regulate CFTR trafficking pathway is catalogued in Reactome (ID: R-HSA-5627083) and involves 1 genes. In the BiohacksAI corpus, 66 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CFTR.