What genes are in the PCNA-Dependent Long Patch Base Excision Repair pathway?

The PCNA-Dependent Long Patch Base Excision Repair pathway involves 4 genes. Key genes include: APEX1, FEN1, PCNA, POLB.

PCNA-Dependent Long Patch Base Excision Repair

Q: What compounds affect the PCNA-Dependent Long Patch Base Excision Repair pathway?

42 compounds in the BiohacksAI corpus have documented interactions with genes in the PCNA-Dependent Long Patch Base Excision Repair pathway (Reactome ID: R-HSA-5651801). These compounds target 4 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-56518014 genes42 compounds

The PCNA-Dependent Long Patch Base Excision Repair pathway (Reactome ID: R-HSA-5651801) involves 4 genes and is affected by 42 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APEX1 FEN1 PCNA POLB

Compounds Affecting PCNA-Dependent Long Patch Base Excision Repair

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Aurintricarboxylic Acid	—	184
3	Oleanolic Acid	—	300
4	Methyldopa	—	297
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Methylene Blue	—	200
7	Quercetin	—	300
8	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
9	Idarubicin	—	299
10	Oxytetracycline	—	300
11	piceatannol	—	300
12	streptonigrin	—	299
13	stigmasterol	—	300
14	4-Hydroxybenzoate-3-Monooxygenase	—	300
15	Ursolic Acid	—	300
16	DEAD-box RNA Helicases	—	169
17	Thioctic Acid	—	298
18	egcg	—	300
19	Rosmarinic Acid	—	300
20	Rutin	—	300
21	Methotrexate	—	289
22	calycosin	—	300
23	Demeclocycline	—	5
24	Dequalinium	—	46
25	Hexachlorophene	—	300
26	Nitroprusside	—	299
27	sp600125	—	117
28	Stavudine	—	298
29	alphitonin [Supplementary Concept] from	—	300
30	Thioctic Acid	—	300
31	Norepinephrine Precursor of epinephrine that is secreted by	—	298
32	Dequalinium	—	136
33	Diiodotyrosine	—	300
34	Epinephrine	—	299
35	Ethidium	—	300
36	Levodopa	—	297
37	Doxycycline	—	999
38	Carmine Coloring matter from	—	300
39	Cisplatin	—	300
40	Demeclocycline	—	297
41	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
42	Triiodothyronine	—	300

About the PCNA-Dependent Long Patch Base Excision Repair Pathway

The PCNA-Dependent Long Patch Base Excision Repair pathway is catalogued in Reactome (ID: R-HSA-5651801) and involves 4 genes. In the BiohacksAI corpus, 42 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APEX1, FEN1, PCNA, POLB.