What compounds affect the Translesion synthesis by POLI pathway?

29 compounds in the BiohacksAI corpus have documented interactions with genes in the Translesion synthesis by POLI pathway (Reactome ID: R-HSA-5656121). These compounds target 2 genes within this pathway.

What genes are in the Translesion synthesis by POLI pathway?

The Translesion synthesis by POLI pathway involves 2 genes. Key genes include: PCNA, POLI.

Translesion synthesis by POLI

REACTOME PATHWAY

Reactome: R-HSA-56561212 genes29 compounds

The Translesion synthesis by POLI pathway (Reactome ID: R-HSA-5656121) involves 2 genes and is affected by 29 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

PCNA POLI

Compounds Affecting Translesion synthesis by POLI

#	Compound	Targets Hit	Studies
1	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
2	Methyldopa	—	297
3	Quercetin	—	300
4	alpha-Linolenic Acid	—	300
5	Aurintricarboxylic Acid	—	184
6	Cefixime	—	300
7	Diiodotyrosine	—	300
8	Ethidium	—	300
9	gamma-Linolenic Acid	—	300
10	Levodopa	—	297
11	Kaempferols	—	300
12	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
13	Methotrexate	—	289
14	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
15	candesartan cilexetil [Supplementary Concept]	—	300
16	Carmine Coloring matter from	—	300
17	Cefotetan	—	299
18	Cisplatin	—	300
19	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
20	Catechin	—	300
21	Idarubicin	—	299
22	Masoprocol	—	300
23	Norepinephrine Precursor of epinephrine that is secreted by	—	298
24	piceatannol	—	300
25	streptonigrin	—	299
26	alphitonin [Supplementary Concept] from	—	300
27	Wortmannin	—	300
28	Oleanolic Acid	—	300
29	Triiodothyronine	—	300

About the Translesion synthesis by POLI Pathway

The Translesion synthesis by POLI pathway is catalogued in Reactome (ID: R-HSA-5656121) and involves 2 genes. In the BiohacksAI corpus, 29 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include PCNA, POLI.