What compounds affect the TNFR2 non-canonical NF-kB pathway pathway?

30 compounds in the BiohacksAI corpus have documented interactions with genes in the TNFR2 non-canonical NF-kB pathway pathway (Reactome ID: R-HSA-5668541). These compounds target 37 genes within this pathway.

What genes are in the TNFR2 non-canonical NF-kB pathway pathway?

The TNFR2 non-canonical NF-kB pathway pathway involves 37 genes. Key genes include: ADRM1, CHUK, CUL1, NFKB2, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6.

TNFR2 non-canonical NF-kB pathway

REACTOME PATHWAY

Reactome: R-HSA-566854137 genes30 compounds

The TNFR2 non-canonical NF-kB pathway pathway (Reactome ID: R-HSA-5668541) involves 37 genes and is affected by 30 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CHUK CUL1 NFKB2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2+7 more

Compounds Affecting TNFR2 non-canonical NF-kB pathway

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
5	Quercetin	—	300
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	candesartan cilexetil [Supplementary Concept]	—	300
8	Disulfiram	—	297
9	4-Hydroxybenzoate-3-Monooxygenase	—	300
10	chrysin	—	300
11	egcg	—	300
12	Genistein	—	300
13	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
14	Kaempferols	—	300
15	Resveratrol	—	298
16	Rutin	—	300
17	Withania	—	500
18	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
19	tamarixetin	—	26
20	withaferin	—	300
21	Amlodipine	—	1,000
22	piceatannol	—	300
23	sp600125	—	117
24	Cetylpyridinium Cationic bactericidal surfactant used as	—	300
25	ninhydrin	—	300
26	Pioglitazone	—	297
27	Harmaline	—	300
28	glaucarubinone	—	10
29	chicoric acid	—	117
30	Podophyllotoxin	—	14

About the TNFR2 non-canonical NF-kB pathway Pathway

The TNFR2 non-canonical NF-kB pathway pathway is catalogued in Reactome (ID: R-HSA-5668541) and involves 37 genes. In the BiohacksAI corpus, 30 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CHUK, CUL1, NFKB2, PSMA1.