What compounds affect the Defective CFTR causes cystic fibrosis pathway?

80 compounds in the BiohacksAI corpus have documented interactions with genes in the Defective CFTR causes cystic fibrosis pathway (Reactome ID: R-HSA-5678895). These compounds target 34 genes within this pathway.

What genes are in the Defective CFTR causes cystic fibrosis pathway?

The Defective CFTR causes cystic fibrosis pathway involves 34 genes. Key genes include: ADRM1, CFTR, PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1.

Defective CFTR causes cystic fibrosis

REACTOME PATHWAY

Reactome: R-HSA-567889534 genes80 compounds

The Defective CFTR causes cystic fibrosis pathway (Reactome ID: R-HSA-5678895) involves 34 genes and is affected by 80 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1 CFTR PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6+4 more

Compounds Affecting Defective CFTR causes cystic fibrosis

#	Compound	Targets Hit	Studies
1	Bortezomib	—	300
2	Reserpine	—	297
3	Genistein	—	300
4	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
5	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
6	Disulfiram	—	297
7	Hexachlorophene	—	300
8	egcg	—	300
9	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
10	Anisomycin	—	247
11	cycloheximide	—	300
12	kenpaullone	—	8
13	Vorinostat	—	299
14	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
15	Hydrocortisone	—	299
16	Betamethasone	—	299
17	Bumetanide	—	299
18	Chlorthalidone	—	299
19	Ethidium	—	300
20	Hydrocortisone	—	298
21	Cervugid [Supplementary Concept]	—	300
22	Medroxyprogesterone Acetate	—	299
23	Vitamin K 3	—	300
24	Mestranol	—	300
25	Nisoldipine	—	297
26	Quinestrol	—	194
27	Budesonide	—	1,000
28	Methylene Blue	—	200
29	Prednisolone	—	1,000
30	6-Aminonicotinamide	—	300
31	alsterpaullone	—	12
32	Hyoscyamine	—	296
33	Beclomethasone	—	300
34	Carbazilquinone	—	48
35	Carbidopa	—	298
36	cardamonin	—	180
37	Desoximetasone	—	86
38	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	—	300
39	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
40	Digoxin	—	299
41	Dinitrochlorobenzene	—	300
42	Flumethasone	—	179
43	Fluocinolone Acetonide	—	295
44	Fluorometholone	—	299
45	Flurandrenolone	—	65
46	gamma-Linolenic Acid	—	300
47	Glyburide	—	298
48	Halcinonide	—	88
49	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	—	115
50	Medroxyprogesterone	—	298

About the Defective CFTR causes cystic fibrosis Pathway

The Defective CFTR causes cystic fibrosis pathway is catalogued in Reactome (ID: R-HSA-5678895) and involves 34 genes. In the BiohacksAI corpus, 80 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, CFTR, PSMA1, PSMA2, PSMA3.