Defective ABCC2 causes DJS
REACTOME PATHWAYThe Defective ABCC2 causes DJS pathway (Reactome ID: R-HSA-5679001) involves 1 genes and is affected by 31 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Defective ABCC2 causes DJS
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Bosentan | — | 298 |
| 2 | Fusidic Acid | — | 300 |
| 3 | Leukotriene D4 | — | 300 |
| 4 | Troglitazone | — | 299 |
| 5 | Abacavir | — | 295 |
| 6 | Antimycin | — | 300 |
| 7 | Bumetanide | — | 299 |
| 8 | cefaclor | — | 299 |
| 9 | cefadroxil | — | 299 |
| 10 | Cefamandole Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as | — | 300 |
| 11 | Cefmetazole | — | 300 |
| 12 | Cefoperazone Semisynthetic broad-spectrum cephalosporin with | — | 300 |
| 13 | Cefoxitin | — | 300 |
| 14 | Ceftriaxone | — | 299 |
| 15 | cefuroxime | — | 299 |
| 16 | Cephradine | — | 298 |
| 17 | Chloramphenicol | — | 297 |
| 18 | Delavirdine | — | 296 |
| 19 | Emtricitabine | — | 292 |
| 20 | Gemfibrozil | — | 297 |
| 21 | Glyburide | — | 298 |
| 22 | Irbesartan | — | 298 |
| 23 | Lamivudine | — | 299 |
| 24 | Leukotriene E4 | — | 300 |
| 25 | Meloxicam | — | 299 |
| 26 | Nitrendipine | — | 299 |
| 27 | Olmesartan Medoxomil | — | 300 |
| 28 | Pioglitazone | — | 297 |
| 29 | Rimonabant | — | 300 |
| 30 | Sulindac | — | 297 |
| 31 | Trazodone | — | 297 |
About the Defective ABCC2 causes DJS Pathway
The Defective ABCC2 causes DJS pathway is catalogued in Reactome (ID: R-HSA-5679001) and involves 1 genes. In the BiohacksAI corpus, 31 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ABCC2.